Inhibitors

A cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC 50 ~3-12 &#181M for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been

A cell-permeable 2,6-disubstituted purine compound that, although originally identified as a reversible, ATP-competitive inhibitor against the conversion of Ins(1,4,5)P 3 to Ins(1,3,4,5)P 4 by IP3K (IC 50 = 18 M [ATP] = 10 &#956M), acts in fact

A cell-permeable aminothioaryl-thiazolo compound that potently inhibits ITK kinase activity (IC 50 = 19 nM [ATP] = 1 M) in an ATP-competitive manner by stabilizing ITK activation loop in a substrate-blocking, inactive conformation, inhibiting Fyn,

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC 50 = 15 nM for murine JAK1), JAK2 (IC 50 = 1 nM), JAK3 (K i = 5 nM), and Tyk2 (IC 50

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC 50 = 15 nM for murine JAK1), JAK2 (IC 50 = 1 nM), JAK3 (K i = 5 nM), and Tyk2 (IC 50

A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 &#181M

A potent, cell-permeable, selective, and reversible inhibitor of c -Jun N-terminal kinase (JNK) (IC 50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP.

A potent, cell-permeable, selective, and reversible inhibitor of c -Jun N-terminal kinase (JNK) (IC 50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP.

A potent, cell-permeable, selective, and reversible inhibitor of c -Jun N-terminal kinase (JNK) (IC 50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP.

A cell-permeable, both NADH and pyruvate-competitive isoform A-selective LDH inhibitor. Exhibits enhanced anticancer activity under hypoxic conditions.

Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Legal Information CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

A cell-permeable, blood-brain-barrier-permeant, and orally available carbamate compound that selectively inhibit MAGL (monoacylglycerol lipase) activity over FAAH (fatty acid amide hydrolase) and 35 other murine brain serine hydrolases, both in