Inhibitors

A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC 50 &lt10 &#181M in cell-free E1 ubiquitination reactions), while exhibiting little or no activity

Application This 2-pyridone ligand developed in the laboratory of Jin-Quan Yu binds to palladium and accelerates non-directed C-H functionalization . Developed for C-H olefination and carboxylation with arene as the limiting reagent, the Wang-Yu

A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC 50 = 4.6 &#181M) and demonstrates growth inhibition in multiple cancer cell lines, not by altering