Inhibitors

A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (K i = 691 nM, K d = 240 nM). AITC is a

A synthetic cell-permeable actinobacteria pyrimidotriazine-dione that selectively disrupts &#946-catenin-Tcf4 interaction (IC 50 = 0.8 &#181M in cell-free binding assays) and inhibits &#946-catenin-regulated cellular transcription activity (IC

A cell-permeable, potent, and highly selective BMPR (bone morphogenetic protein receptor) inhibitior (IC 50 against human ALK2/BMPR-I = 107.9 nM) that exhibits no inhibitory activity against ALK5, AMPK, FLK1/KDR/VEGRF2, or PDGFR&#946.

A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K i = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (K i = 5080 nM and 9640 nM for hCA I

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC 50 = 110 nM, K i = 77 nM) with greater selectivity than TBB (Cat. Nos.

Synonym(s): Ac-LEHD-CMK Formula: C24H35ClN6O9 Formula weight: 587.02 CAS Number: 403848-57-7 Harmonized Tariff Code:  2924.19

A cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC 50 = 9.

A cell-permeable nitroindolo-guanidinohydrazone compound that acts as a potent, ATP-competitive, and highly selective Chk2 inhibitor (IC 50 = 138 and 570 nM against the phosphorylation of histone H1 by Chk2 in the presence of 10 &#181M and 1 mM of

Native, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma.

A cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC 50 = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (

A cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (K i = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A).

Dipeptidyl peptidase IV (DPP IV)&nbspis a member of the&nbspprolyl-specific&nbspproteases family. It is a dimeric type II integral membrane glycoprotein that is broadly expressed in&nbspthe&nbspepithelial and nonepithelial tissues.