Inhibitors

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No.

A potent and ATP-competitive inhibitor of GSK-3 (K i = 24 nM). An aminopyrazole compound that acts as a potent and ATP-binding site inhibitor of GSK-3 with a K i of 24 nM.

A potent and ATP-competitive inhibitor of GSK-3 (K i = 24 nM). An aminopyrazole compound that acts as a potent and ATP-binding site inhibitor of GSK-3 with a K i of 24 nM.

A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pK i = 7.91, 7.

A cell-permeable quinazolinamine compound that acts as a potent and reversible inhibitor of G9a and GLP HMTases (histone methyltransferases) (IC 50 = &#8804 15 and 19 nM for G9a and GLP, respectively) and displays ~15-fold greater selectivity over

A cell-permeable, 2H-chromen-2-one based compound that competitively binds to Hu antigen R (HuR K i = 350 nM) and disrupts the interaction of HuR and adenine- and uridine-rich element (ARE) of target mRNAs. Displays dose-dependent binding to

A cell-permeable quinoxaline compound that displays anti-inflammatory properties. Acts as a potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC 50 = ~ 300 nM).

A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC 50 = ~ 3-12 &#181M for IKK-2 homodimer, IKK-1/IKK-2

Application Imidazolo-oxindole PKR inhibitor C16 has been used: to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid

Application Imidazolo-oxindole PKR inhibitor C16 has been used: to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid

A panel containing 13 potent, selective, reversible and cell-permeable inhibitors, 1 potent, selective and reversible inhibitor, and 1 potent, selective, irreversible and cell-permeable inhibitor useful for the study of multiple signaling pathways

A cell-permeable, potent, and selective inhibitor of Akt1/Akt2 activity (IC 50 = 58 nM, 210 nM, and 2.12 &#181M for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).