Protein Kinase Modulators

A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC 50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 &#181M

Application For use as a substrate in PKC kinase assays. Research Category All Quality Routinely evaluated in a kinase assay.

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Biochem/physiol Actions Protein Target: Rsk2 Target Sub-Family: AGC Quality Routinely evaluated as a substrate for p90 Rsk-2 and p70 S6 Kinase. Physical form Lyophilized powder Storage and Stability Lyophilized: Stable for 2 years at -20&#176C

A cell-permeable hydroxymethylpyrrolidine compound that acts as a high affinity ( K d = 5 nM, k off t 1/2 = 8.5 min), but poor, sphingosine kinase-1/SphK1 substrate (1/1,500 of sphingosine processivity) and potently inhibits against SphK1-catalyzed

A cell permeable, orally bioavailable thiazolidine-2,4-dione derivative that acts as a selective, sphingosine competitive inhibitor of spingosine Kinase -2 (SphK2 IC 50 = 4.3 &#181M Ki = 6.