Biochemicals & Molecular Biology

Both D- and L-forms are reagents for kinetic resolution of racemic allylic alcohols and α-furfuryl amides by enantioselective epoxidation.

(+)-Igmesine hydrochloride.

(+)-Igmesine hydrochloride.

(+)-Isomenthone.

(+)-Isomenthone.

(+)-Isomenthone.

Biochem/physiol Actions (+)-JQ-1 carboxylic acid is a potent BET (bromodomain and extra terminal domain) inhibitor. (+)-JQ-1 carboxylic acid could serve as precursor to synthesize PROTACs and other conjugates.

Biochem/physiol Actions (+)-JQ-1 carboxylic acid is a potent BET (bromodomain and extra terminal domain) inhibitor. (+)-JQ-1 carboxylic acid could serve as precursor to synthesize PROTACs and other conjugates.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.