Radiolabeled Receptor Modulators

Potent, selective and non-competitive NMDA receptor antagonist (Ki = 30.5 nM) acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux.

Potent, selective and non-competitive NMDA receptor antagonist (Ki = 30.5 nM) acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux.

(R)-Olacaftor ((R)-VX-440) is a Cystic fibrosis transmembrane conductance regulator ( CFTR ) modulator. (R)-Olacaftor has good potential for the study of cystic fibrosis (CF).

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT 2C receptor agonist with a K i of 4 nM and an EC 50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT 2C than 5-HT 2A and 5-HT 2B receptors. (Rac)-WAY-161503 has anti-obesity

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT 2C receptor agonist with a K i of 4 nM and an EC 50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT 2C than 5-HT 2A and 5-HT 2B receptors. (Rac)-WAY-161503 has anti-obesity

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT 2C receptor agonist with a K i of 4 nM and an EC 50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT 2C than 5-HT 2A and 5-HT 2B receptors. (Rac)-WAY-161503 has anti-obesity

Biochem/physiol Actions Water soluble adenosine receptor antagonist with slight selectivity for A 1 receptors.

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist：1.to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist：1.to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist：1.to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist：1.to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized

Selectively blocks Nav1.6 channels (IC₅₀ = 7.8 nM in Xenopus oocytes versus IC₅₀ values of 1.3, 0.34, 0.99, 78.5, 1.3, and &gt30 &microM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively).