Radiolabeled Receptor Modulators

Selectively blocks Nav1.6 channels (IC₅₀ = 7.8 nM in Xenopus oocytes versus IC₅₀ values of 1.3, 0.34, 0.99, 78.5, 1.3, and &gt30 &microM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively).

5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT ( HY-112061 ), is a modulator of 5-HT 1A with a K i of 53 nM for 5-HT 1A bindingIn Vitro5-HT1A modulator 2 hydrochloride (compound 3) binds to 5-HT 1A with a K i of 53 nM. MCE has not

Solutions should be freshly prepared and protected from exposure to light.6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals.product description：6-Hydroxydopamine is a selective catecholaminergic neurotoxin.

Biochem/physiol Actions TRPV1 (V1) vanilloid receptor antagonist.

Application 8-Bromoadenosine 5&#8242&#8242-monophosphate (8-Br-AMP) is an analogue of 5′-AMP useful for receptor mapping studies as a starting structure for 8-modified 5′-AMP derivatives and for synthesis of poly-8-bromoriboadenylic acid.

Biochem/physiol Actions Selective A 1 adenosine receptor antagonist. Features and Benefits This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction.

9(R)-HETE is an enantiomer which makes up 50% of (&plusmn)9-HETE (Item No. 34400). At a concentration of 300 nM, 9(R)-HETE activates RXR&gamma-dependent transcription 1.5 fold relative to a control.

Amino Acid Sequence Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met-NH2 Application Substance P is a tachykinin family 11 amino acid neuropeptide involved in neurotransmission and neuromodulation. Substance P acts via the neurokinin-1 receptor

Amino Acid Sequence Suc-Asp-Phe-NMe-Phe-Gly-Leu-Met-NH2 Application Senktide (succinyl-[Asp6,Me-Phe8] substance P (6-11)), a substance P analogue, is used as a selective agonist of tachykinin NK-3 (or SP-N) receptors.

A 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM) shows weaker affinity for EP receptors, with Ki values of &gt 100 nM for EP1-3 and &gt 10 nM for EP4.

A 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM) shows weaker affinity for EP receptors, with Ki values of &gt 100 nM for EP1-3 and &gt 10 nM for EP4.

AM-630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 μM and 31.2 nM, respectively. AM630 has been shown to display 165-fold selectivity over CB1 receptors and behave as a weak partial/inverse