Kinase Inhibitors

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6

N-terminal 6His-tagged recombinant human Abl, residues 27-end containing the Q252H mutation. The Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients.

Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor./nAc-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury)

Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor./nAc-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury)

Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor./nAc-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury)

Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase.An inhibitor of the transcription of PPARα, the coactivation of PPARα.

Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase.An inhibitor of the transcription of PPARα, the coactivation of PPARα.

Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase.An inhibitor of the transcription of PPARα, the coactivation of PPARα.

Acalabrutinib (ACP-196) Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has

A potent cytotoxic chloromethylketone used against human-lineage and T-lineage acute lymphoblastic leukemia cell lines.

Adarotene (ST1926) is an effective apoptosis inducer and surprisingly produced DNA damage.ST1926 exhibites a potent antiproliferative activity on a large panel of human tumor cells.