Phospholipase Inhibitors

Biochem/physiol Actions Useful in screening caspase inhibitors, studying enzyme kinetics and regulation, determining target substrates, as well as serving as positive controls in caspase activity assays and Western blot analysis. Unit Definition

Amino Acid Sequence Ac-Leu-Glu-His-Asp-al Biochem/physiol Actions Ac-Leu-Glu-His-Asp-al, or Ac-LEHD-CHO, is a cell-permeable tetrapeptide aldehyde. It is an inhibitor of caspase-9.

A cell-permeable phenylimidazopyridinyl-methoxy coumarin compound that inhibits caspase-3 and caspase-6 activities (IC 50 = 35 and 38 &#181M, respectively) by targeting both the large and small subunit active sites. Kinetic studies with 1541 and

A cell-permeable inhibitor of caspase-1 (ICE Interleukin-1&#946 Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (K i = 1 nM).

An enhanced cell-permeable, non-toxic, orally available masked aspartaldehyde prodrug that is converted to its active metabolite, VRT-043198, both in vitro and in vivo via hydrolytic cleavage by esterases. The active metabolite displays anti-

A cell-permeable and irreversible inhibitor of caspase-2 (ICH-1) An irreversible inhibitor of caspase-2 (ICH-1). Biochem/physiol Actions Cell permeable: yes Primary Target caspase-2 Product does not compete with ATP.

Antigen: human caspase-3 amino acids 166-183 Host: rabbit Cross Reactivity: (+) human, mouse, baboon, and hamster caspase-3 recognizes both the proform and active subunits of caspase-3 Application(s): WB and IHC Caspase-3 is a key effector caspase

A fluorogenic substrate for caspase-6 (Mch2). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm emission maximum: ~505 nm).

caspase-8 inhibitor is a reversible inhibitor of caspase-6, -8 and granzyme B. It is also known to inhibit caspase-10.

caspase-8 inhibitor is a reversible inhibitor of caspase-6, -8 and granzyme B. It is also known to inhibit caspase-10.

CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC 50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.In VitroCAY10650 (12 nM: 30 min: neutrophils) inhibits the expression of the

CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC 50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.In VitroCAY10650 (12 nM: 30 min: neutrophils) inhibits the expression of the