Phospholipase Inhibitors

Application：It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool

Application U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na + channel (ENaC) function in gerbil Reissner&#8242:s membranes (RMs) . U-73122 has also been used to study local

General description U-73343 is used to assess the involvement of G protein-coupled 1-phosphatidylinositol-phosphodiesterase or phospholipase C in receptor-mediated cell activation. It functions downstream of phospholipase C to block

General description U-73343 is used to assess the involvement of G protein-coupled 1-phosphatidylinositol-phosphodiesterase or phospholipase C in receptor-mediated cell activation. It functions downstream of phospholipase C to block

Application Urolithin A has been used: to test its antileukemic activities on leukemic cell lines by in vitro cell proliferation assay as a mitophagy activator to study the effect of phosphoglycerate mutase 5 (PGAM5) expression on mitophagic

Biochem/physiol Actions VU0155069 is a PLD1-selective catalytic site-targeting phospholipase D inhibitor (PLD1/2 IC50 = 46 nM/933 nM by cell-free enzymatic assays: substrate = di-palmitoyl-PLC) that selectively suppresses the cellular PLD activity

Biochem/physiol Actions VU0155069 is a PLD1-selective catalytic site-targeting phospholipase D inhibitor (PLD1/2 IC50 = 46 nM/933 nM by cell-free enzymatic assays: substrate = di-palmitoyl-PLC) that selectively suppresses the cellular PLD activity

Biochem/physiol Actions VU0155072 is a PLD2-selective, PH domain-targeting allosteric phospholipase D inhibitor (human PLD2/PLD1 IC 50 = 140 nM/5.1 &#956:M vs.

Biochem/physiol Actions VU0155072 is a PLD2-selective, PH domain-targeting allosteric phospholipase D inhibitor (human PLD2/PLD1 IC 50 = 140 nM/5.1 &#956:M vs.

selective inhibitors of mutant H1047R phosphoinositide- 3-kinase (PI3Ka).

antivirulence agent: antimalarial HDP inhibitor:.

Biochem/physiol Actions YU142670 is a selective inhibitor against OCRL1/INPP5F (IC50 = 0.71 &#956:M: substrate = PI(4,5)P2) and OCRL2/INPP5B (IC50 = 0.