Protease Inhibitors

Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.In VitroCapzimin (3027) shows 80-fold selectivity for Rpn11 over Csn5, 10-fold over AMSH and 6-fold over BRCC36 (IC 50 =30 μM, 4.5 μM and 2.3 μM respectively.

Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.In VitroCapzimin (3027) shows 80-fold selectivity for Rpn11 over Csn5, 10-fold over AMSH and 6-fold over BRCC36 (IC 50 =30 μM, 4.5 μM and 2.3 μM respectively.

Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.In VitroCapzimin (3027) shows 80-fold selectivity for Rpn11 over Csn5, 10-fold over AMSH and 6-fold over BRCC36 (IC 50 =30 μM, 4.5 μM and 2.3 μM respectively.

Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.In VitroCapzimin (3027) shows 80-fold selectivity for Rpn11 over Csn5, 10-fold over AMSH and 6-fold over BRCC36 (IC 50 =30 μM, 4.5 μM and 2.3 μM respectively.

Biochem/physiol Actions Capzimin can be used as a therapeutic for cancer treatment. Capzimin dimer is the stable precursor form of capzimin.

Biochem/physiol Actions Capzimin can be used as a therapeutic for cancer treatment. Capzimin dimer is the stable precursor form of capzimin.

Casein is considered to be a generic substrate for a broad spectrum of proteases. As native casein this fluoresceinated casein is hydrolyzed by many proteases, and widely used for fluorimetric measurement of protease activity. In the intact

Amino Acid Sequence Ac-Leu-Glu-Glu-Asp-pNA Application Caspase 13 (ERICE), an orthologue of human caspase 4, is a cysteine protease which may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the LEED

Amino Acid Sequence Ac-Leu-Glu-Glu-Asp-AMC Application Caspase 13 (ERICE), an orthologue of human caspase 4, is a cysteine protease which may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the LEED

A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases. A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and

A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases. A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and

Cathepsin B is encoded by the gene CTSB and is located in the human chromosome at 8p23.1.