Protease Inhibitors

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity.Anti-infection SARS-CoV Virus Protease ML188.

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity.Anti-infection SARS-CoV Virus Protease ML188.

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity.Anti-infection SARS-CoV Virus Protease ML188.

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity.Anti-infection SARS-CoV Virus Protease ML188.

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity.Anti-infection SARS-CoV Virus Protease ML188.

Biochem/physiol Actions ML323 induces viral replication in vitro and in vivo . It may act as a potential candidate for the intervention of diseases like rheumatoid arthritis and systemic lupus erythematosus.

Biochem/physiol Actions ML323 induces viral replication in vitro and in vivo . It may act as a potential candidate for the intervention of diseases like rheumatoid arthritis and systemic lupus erythematosus.

InformationML346 ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.TargetsHSP70.

InformationML346 ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.TargetsHSP70.

InformationML346 ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.TargetsHSP70.

MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31

MLN9708在水溶液或血浆中立即水解为具有具有生物活性的MLN2238。MLN2238抑制20S proteasome的胰凝乳蛋白酶等蛋白水解位点（β5），无细胞试验中IC50/Ki为3.4 nM/0.93 nM，对β1作用效果稍弱，对β2几乎没有抑制活性。.