Topoisomerases

Biochem/physiol Actions BNS-22 is a derivative of natural product GUT-70 isolated from the stem bark of Calophyllum brasiliense exhibits antiproliferative activity against human cancer cells. It appears that BNS-22 is a specific

A cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells.

4-ethyl-4-hydroxy-1H-pyrano[3&rsquo,4&rsquo:6,7]indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione A cytotoxic quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Topo I). Supplied as 1ml 2mM Features Synonym: CPT CAS Number: 7689-03-4

Amino Acid Sequence Ser-Ser-Met-Lys-Leu-Ser-Phe-Arg-Ala-Arg-Ala-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Pro-Gln-Leu Biochem/physiol Actions The catestatin peptide is produced from its precursor chromogranin A protein. Catestatin is a cationic and hydrophobic

Product Describtion:Chartreusin is a potent anti-proliferative agent originally derived from Streptomyces chartreusis. This compound has been shown to be a potent inhibitor of the catalytic activity of Topo II (topoisomerase II). Experiments have

Product Describtion:Chartreusin is a potent anti-proliferative agent originally derived from Streptomyces chartreusis. This compound has been shown to be a potent inhibitor of the catalytic activity of Topo II (topoisomerase II). Experiments have

Conjugate of N-acetyl-cysteine and benzylisothiocyanate. It

Conjugate of N-acetyl-cysteine and benzylisothiocyanate. It

Conjugate of N-acetyl-cysteine and benzylisothiocyanate. It

Conjugate of N-acetyl-cysteine and methylisothiocyanate. It

InformationDaunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibitsDNAsynthesis withKiof 0.02 μM in a cell-free assay. Daunorubicin is atopoisomerase IIinhibitor that inducesapoptosis.In vitroAt drug

Product description：Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).