Enzyme inhibitors and enzyme substrates

PD-169316.

PD-169316.

PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM: little effect noted against PGDFR, FGFR, CSF-1, InsR and Src.A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase.

PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM: little effect noted against PGDFR, FGFR, CSF-1, InsR and Src.A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase.

PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM: little effect noted against PGDFR, FGFR, CSF-1, InsR and Src.A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase.

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.Potent inhibitor of FGF and VEGF (Flt/Flk) receptors.

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.Potent inhibitor of FGF and VEGF (Flt/Flk) receptors.

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.Potent inhibitor of FGF and VEGF (Flt/Flk) receptors.

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, 100-fold more selective for MEK1/2 than MEK5A MEK inhibitor.

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, 100-fold more selective for MEK1/2 than MEK5A MEK inhibitor.

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, 100-fold more selective for MEK1/2 than MEK5A MEK inhibitor.

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, 100-fold more selective for MEK1/2 than MEK5A MEK inhibitor.