Biotin-VAD-FMK is a cell permeable biotin-labeled pan-caspase inhibitor used to identify active caspases in cell lysates. Biotin-VAD-FMK is an irreversible caspase inhibitor that covalently binds to the active cavity of a wide spectrum of active caspases. Affinity labeling of active caspases with biotin-VAD-fmk was carried out under conditions where more than 95% of caspase-3-like activity was inactivated in lysates from TNFα/ActD-treated cells. Biotin-VAD-FMK is an irreversible, pancaspase inhibitor. Inhibits TNFα-mediated apoptosis in vitro (IC50 = 0.7 μM). Specifications and Purity: 98%. Molecular Formula: C30H49FN6O8S. Molecular Weight: 672.81. PubChem CID: 25108682. Isomeric SMILES: C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)CCCCCNC(=O)CCCC[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B333580-SCI_2c9f013498d1d6fd218fe11f23c01abd.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B333580-5mg
- CAS:
- 1135688-15-1
- Product Size:
- 5mg
- Precautionary Statement Codes:
- P264
