BIOTRACKER RED MAO-A LIVE CELL DYE (C005B-314934)

General description

Monoamine oxidases (MAOs) are important enzymes that catalyze the transformation of various neurotransmitters including serotonin, dopamine, and phenethylamine. They have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate the isoforms by using fluorescence detection/imaging technology is biologically relevant, but challenging with currently available chemical tools.

BioTracker Red MAO-A Live Cell Dye is a specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity. This probe may be used to detect MAO-A enzymatic activities in various biological samples, including live mammalian cells, mouse and human tissues by using two-photon fluorescence microscopy with minimal cytotoxicity.

Reference:
1. Fang, H., Zhang, H., Li, L., Ni, Y., Shi, R., Li, Z., ... & Huang, W. (2020). Rational Design of a Two?Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angewandte Chemie, 132(19), 7606-7611.

Application

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

Features and Benefits

Specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity in live cells, mouse and human tissues.

Physical form

Lyophilized. Yellow solid.

Storage and Stability

Store at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

Other Notes

Live cell fluorescent imaging

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.