BIOTRACKER TINIR HMOX2 LIVE CELL DYE

General description

Increasing evidence suggests that a small population of tumor initiating cells (TIC) or cancer stem cells (CSC) are responsible for tumorigenesis and resistance to conventional anti-cancer therapies. Heme oxygenase 2 (HMOX2) has recently been identified as a novel biomarker for tumor initiating cells. BioTracker TiNIR HMOX2 Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and isolation of HMOX2 expressing tumor initiating cells. At low concentrations or a single injection of high concentration, TiNIR (tumor initiating cell probe with near infrared) is useful for the isolation of TIC in vitro and in vivo visualization in tumor model animals, respectively. At high concentrations or repeated treatments, TiNIR has been shown to inhibit the function of HMOX2 and induce tumor cell death by accumulating ROS in cancer cells .

Spectral Properties
Absorbance: 805 nm
Emission: 825 nm

Reference:1. Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.

Application

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

Features and Benefits

Near-Infrared probe for detection and isolation of HMOX2 expressing tumor initiating cells.

Physical form

Lyophilized. Green solid.

Storage and Stability

Store at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

Other Notes

Live cell fluorescent imaging

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.