BIP-135 is an inhibitor of glycogen synthase kinase-3 (GSK-3), and is found to be realatively selective for GSK-3β at 21 nM over GSK-3α with modest activity toward PKCβ (β1: 980 nM; β2: 219 nM), DYRK1B (590 nM), and PI3Kα (870 nM). BIP-135 was shown to have neuroprotective effects over cortical neuron model of oxidative stress. In a mouse model of spinal muscular atrophy, BIP-135 elevated SMN protein levels in vitro and extended median survival. Specification: 0.98 Molecular Formula: C21H13BrN2O3 Molecular Weight: 421.24 PubChem CID: 16741475 Isomeric SMILES: CN1C=C(C2=C1C=CC(=C2)Br)C3=C(C(=O)NC3=O)C4=COC5=CC=CC=C54 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B338804-SCI_77d108780287b2056f7be0b36498d622.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- B338804-5mg
- CAS:
- 941575-71-9
- Health Hazards:
- Toxic
- Product Size:
- 5mg
- Hazard Statement Codes:
- H301
- Precautionary Statement Codes:
- P264:P270:P330:P405:P501
