BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). Application：BL-1249 has been used:as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissuesas a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell lineas a TREK1 and TREK2 activator in mice. Specification: 0.98 Molecular Formula: C17H17N5 Molecular Weight: 291.35 PubChem CID: 16078951 Isomeric SMILES: C1CCC2=C(C1)C=CC=C2NC3=CC=CC=C3C4=NNN=N4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B286784-SCI_89961351d05460e42b3755665f067276.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B286784-25mg
- CAS:
- 18200-13-0
- Product Size:
- 25mg
- Hazard Statement Codes:
- H315:H319:H335:H413
- Precautionary Statement Codes:
- P261:P264:P271:P273:P280:P302+P352:P304+P340:P305+P351+P338:P362+P364:P405:P403+P233:P501
