BL-1249 (C15-1220-511)

Catalog No.: C15-1220-511
Manufacturer No.: B2186-10MG
Manufacturer Name: Sigma-Aldrich
Quantity: 10
Unit of Measure: MG

Price: $479.39

List Price: $532.65

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme. Application BL-1249 has been used: as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues as a TWIK related

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Description
Specifications

General description

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.

Application

BL-1249 has been used:

as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
as a TREK1 and TREK2 activator in mice.

Biochem/physiol Actions

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.

BL-1249 is a putative activator of potassium TREK-1 channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:: 41115700
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: B2186-10MG

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