BMO Screen

Our BMO kits enable, in three simple steps, synthesis of metabolites directly from the parent drug. Key Benefits: Fast nexpensive Rapid optimization Reproducible Scaleable to mg Convenient room temperature reagents Easy to use HepatoChem has developed a revolutionary way to screen, optimize, and produce metabolites directly from drug candidates. The BMO Kit exploits an optimized panel of catalytic chemical reaction conditions using organometallic catalysts in a multi-well parallel format. This tool mimics the suite of cytochrome P450 enzymes (CYP) present in human hepatocytes, offering the researcher a unique synthetic chemical liver. Our innovative approach is based on a diverse panel of chemical conditions that mimics the main reactions occurring during drug metabolism. This panel, which utilizes biomimetic catalysts, including metalloporphyrins, is used to quickly find reaction conditions that generate target drug metabolites. The HepatoChem tool, basically a chemical liver, is analogous to the panel of cytochromes P450 present in the human liver, but with the advantage of the scalability of chemistry. When a reaction condition is identified, it is optimized and scaled up to produce mg quantities of metabolites. Our series of easy-to-use kits is suitable for the preparation of metabolites for both MSMS and NMR. Possible Biotransformation Reactions: Aliphatic Hydroxylation N- and O-Dealkylation N- and S-Oxidation Cleavage and rearrangement Formylation Order corresponding optimization kit.      Complete kit includes all solvents and reagents for 2x25 screening reaction conditions.