InformationBMS-794833 is a potent ATP competitive inhibitor ofMet (c-Met)/VEGFR2withIC50of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.In vitroBMS794833 also inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with IC50 of 39 nM.In vivoIn GTL-16 human gastric tumor xenografts model, BMS798433 shows greater than 50% TGI for at least one tumor doubling time with no overt toxicity observed during 14 days. BMS798433 also shows complete tumor stasis at a dose of 25 mg/kg against U87 glioblastoma model.Cell Datacell lines：Concentrations：~ 1 μMIncubation Time：72 hoursPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C23H15ClF2N4O3 Molecular Weight: 468.84
- UPC:
- 51112103
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B407931-1ml
- CAS:
- 1174046-72-0
- Product Size:
- 1ml
