BMT-090605 hydrochloride (C09-1113-502)

BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC 50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC 50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic painIn VitroBMT-090605 hydrochloride shows AAK1inhibitory activity with an IC 50 of 0.63 nM. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC 50 values of 45 nM and 60 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoBMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model) Dosage: 0.3-3 µg/rat Administration: Intrathecal Result: Caused a dose-dependent reduction in thermal hyperalgesia.Form:SolidIC50& Target:IC50: 0.6 nM (AAK1),45 nM (BIKE),60 nM (GAK). Specification: 0.99 Molecular Formula: C21H25ClN4O2 Molecular Weight: 400.9