General description
A trityl-protected derivative which increases the solubility of glutamine during the coupling step in SPPS [1]. Its use gives higher yields and lower by-product formation. During the following coupling cycles the temporary side-chain protection is removed.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.
Linkage
Replaces: 04-12-0188
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -3.0 - -2.0 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51442707
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8530750025