General description
Standard building block for introduction of tryptophan by Boc SPPS. The formyl group is stable to standard high HF cleavage but can be removed by HF containing thiophenol [1,2,3]. The formyl group can also be removed with piperidine in DMF prior to HF cleavage.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] M. Ohno, et al. (1973) Bull. Chem. Soc. Jpn., 46, 3280.
[2] W. F. Heath, et al. (1982) J. Chem. Soc., Chem. Commun., 896.
[3] G. R. Matsueda (1982) Int. J. Peptide Protein Res., 20, 26.
Linkage
Replaces: 04-12-0087
Analysis Note
Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(0811)): ≥ 98 %
Purity (TLC(011A)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 41115717
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8530220025