Bomedemstat dihydrochloride (C09-1113-983)

Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride sAppearance:SolidIC50& Target:KDM1/LSD1In Vitro:Bomedemstat dihydrochloride selectively inhibits proliferation and induces apoptosis of Jak2 V617F cells by concomitantly increasing expression and methylation of p53. Bomedemstat (50 nM-1 μM; 96 h; SET-2 cells) dihydrochloride enhances survival, indIn Vivo:Bomedemstat (oral gavage; 45mg/kg; once daily; 56 d) dihydrochloride normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis. MCE has not independently confirmed the acBiological Activity:Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride s. Specifications and Purity: 99%. Molecular Formula: C28H36Cl2FN7O2. Molecular Weight: 592.54.