GSK3α (Cell-free assay); GSK3β (Cell-free assay); GSK3α (Cell-free assay) 66 nM; 515 nM(Kd); 4.8 μM(Kd)In vitroBRD0705 inhibits kinase function and does not stabilize β-catenin, mitigating potential neoplastic concerns. BRD0705 induces myeloid differentiation and impairs colony formation in AML cells while no effect is observed on normal hematopoietic cells.BRD0705 impairs leukemia initiation and prolongs survival in AML mouse models.Cell Research(from reference)Cell lines：HEK 293T, HL-60, U937, TF-1, NB-4, MV4–11, MOLM-13, Mononuclear cells Concentrations：20 μM Incubation Time：24 hours. Specifications and Purity: 98%. Molecular Formula: C2OH23N3O. Molecular Weight: 321.42. PubChem CID: 136980453. Isomeric SMILES: CC[C@@]1(C2=C(NC3=C1C(=O)CC(C3)(C)C)NN=C2)C4=CC=CC=C4.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B414436-1mg
- CAS:
- 2056261-41-5
- Product Size:
- 1mg
