Brefeldin A (C007B-029438)

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO. Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3. Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion. Specification: from Penicillium brefeldianum, ≥98% (HPLC) MDL Number: MFCD12913297 Molecular Formula: C16H24O4 Molecular Weight: 280.36 PubChem CID: 5287620 Isomeric SMILES: C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C/C(=O)O1)O)O Beilstein Registry Number: 25191 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B102375-SCI_4da9be0eb8a9c416180f9b7f3bd25ae7.pdf