BRIVANIB (C005B-308607)

Catalog No.: C005B-308607
Mfr. No.: SML3671-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $288.66

List Price: $320.73

Biochem/physiol Actions Brivanib (BMS-540215) is an orally active, ATP-competitive FGF &: VEGF receptor tyrosine kinase inhibitor (VEGFR-1/2/3 IC50 = 380/25/10 nM: FGFR-1/2/3 IC50 = 148/125/68 nM). Brivanib inhibits VEGF-stimulated and basic

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Biochem/physiol Actions

Brivanib (BMS-540215) is an orally active, ATP-competitive FGF & VEGF receptor tyrosine kinase inhibitor (VEGFR-1/2/3 IC50 = 380/25/10 nM; FGFR-1/2/3 IC50 = 148/125/68 nM). Brivanib inhibits VEGF-stimulated and basic FGF-stimulated proliferation in endothelial cultures (IC50 = 40 & 276 nM, respectively) and displays antitumor efficacy in vivo (30-90 mg/kg via daily p.o. in mice with H3396 xenografts).

UPC:: 51323001
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3671-5MG
CAS:: 649735-46-6

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