Brofaromine (C09-1113-280)

Brofaromine (CGP 11305A) is a monoamine oxidase ( MAO ) inhibitor with IC 50 of 0.2 μM for MAO-A .In VitroIn order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 0.2  μM (MAO-A). Specification: 0.98 Molecular Formula: C14H16BrNO2 Molecular Weight: 310.19 PubChem CID: 44571 Isomeric SMILES: COC1=CC(=C2C(=C1)C=C(O2)C3CCNCC3)Br