Bryostatin 1 (C15-1284-227)

Application

Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in mice. It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.

Biochem/physiol Actions

Bryostatin 1 (Bry1) is a macrocyclic lactone. This synaptogenic compound is obtained from the marine bryozoan Bugula neritina. Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders. It possesses antidepressant activity, when administered intracebroventricularly. Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.

Macrolactone isolated from the marine bryozoan Bugula neritina that initially activates and subsequently down-regulates protein kinase C (PKC). More potent than phorbol myristate acetate for translocating PKCδ and ε.

Other Notes

Binds to glass and plastic in aqueous solutions

Molecular Weight: 905.03. Empirical Formula: C₄₇H₆₈O₁₇. Quality Level: 100. Assay: ≥. 99%. form: solid. color: white. solubility: DMSO: soluble, ethanol: soluble. storage temp.: −. 20°C. SMILES string: [H]\C(C(: O)OC): C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(: O)O[C@H](C[C@]4([H])C\C(: C(\[H])C(: O)OC)[C@H](OC(: O)\C: C\C: C\CCC)[C@@](O)(O4)C(C)(C)\C: C\[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C): O)C3(C)C. InChI: 1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1. InChI key: MJQUEDHRCUIRLF-TVIXENOKSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).