BSJ-04-122 (C09-1113-410)

BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancerIn VitroBSJ-04-122 has inhibitory activity for MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 (1, 5, 10 μM; 6 h) induces robust reduction of JNK phosphorylation. BSJ-04-122 (0, 1.25, 2.5, 5, 10, 20 μM; 72 h) shows enhanced antiproliferative effects when combination with JNK-IN-8. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 1, 5, 10 μM Incubation Time: 6 h Result: Significantly decreased levels of T183/Y185 pJNK at 5 μM. Cell Proliferation AssayCell Line: MDA-MB-231 cells Concentration: 1-100 μM; 0, 1.25, 2.5, 5, 10, 20 μM Incubation Time: 72 h Result: Exhibited antiproliferative effects when combination with JNK-IN-8 in MDA-MB-231 cells.Form:SolidIC50& Target:IC50: 4 nM (MKK4),181 nM (MKK7). Specifications and Purity: 99%. Molecular Formula: C15H12ClN5O. Molecular Weight: 313.74.