BT2 (C15-1720-353)

Catalog No.: C15-1720-353
Mfr. No.: SML3706-50MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $570.70

List Price: $634.11

Biochem/physiol Actions BT2 is an orally active, allosteric mitochondrial branched-chain α:-ketoacid dehydrogenase (BCKD) kinase (BCKDK or BDK) inhibitor (IC50 = 3.19 μ:M) that induces BDK dissociation from the BCKD complex (BCKDC) with

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Description
Specifications

Biochem/physiol Actions

BT2 is an orally active, allosteric mitochondrial branched-chain α-ketoacid dehydrogenase (BCKD) kinase (BCKDK or BDK) inhibitor (IC50 = 3.19 μM) that induces BDK dissociation from the BCKD complex (BCKDC) with superior pharmacokinetics and metabolic stability than (S)-CPP. BT2 increases cellular BCKDC activity in cultures (40 μM; MEF & murine hepatocytes) and induces BDK degradation in mice & rats in vivo, effectively upregulating tissue BCKDC activity and downregulating plasma branched-chain amino acid (BCAA) level. Typical dosing range: 40-250 μM (in cultures or cell-free), 20-40 mg/kg (ip. or po. in vivo; mice & rats) or 200 mg/kg diet.

UPC:: 51162608
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3706-50MG
CAS:: 34576-94-8

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