Bufalin (C007B-046262)

Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis.Bufalin is a cardiotonic steroid[5] and is digoxin-like component of Chan Su.Bufalin has been used:• to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs)• as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes• to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib. Specification: 98% (HPLC) Molecular Formula: C24H34O4 Molecular Weight: 386.52 PubChem CID: 9547215 Isomeric SMILES: C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@H]4C5=COC(=O)C=C5)O)C)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B170472-SCI_d7103c080a58faecf2b9efe4b805b9f2.pdf