BV-6 TFA salt (C09-0785-805)

InformationBV-6 is a SMAC mimetic, dualcIAPandXIAPinhibitor.TargetscIAP ; XIAPIn vitroBV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential.Cell Research(from reference)Cell lines：HCC193 and H460 cells Concentrations：~30 μM Incubation Time：~48 hours. Specification: 0.98 Molecular Formula: C70H96N10O8.xCF3COOH Molecular Weight: 1205.57（free）