C-Reactive Protein (C15-1318-340)

General description

C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein, which belongs to the pentraxin family. It is a highly conserved plasma protein produced mainly in liver hepatocytes. It is also synthesized by lymphocytes, smooth muscle cells, macrophages, endothelial cells, and adipocytes.

Application

C-reactive protein (CRP) has been used:

• as a model analyte for interference-reduced detection of CRP in serum using non-competitive sandwich immunoassay in combination with surface plasmon field-enhanced fluorescence spectroscopy (SPFS)
• to determine the involvement of collectin placenta 1 (CL-P1) in CRP-mediated complement activation and to investigate the downstream effects of this complement activation
• to examine to study the effects of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) on CRP-induced complement activation by interacting with CRP to develop an inflammatory pathogenic response

Biochem/physiol Actions

C-reactive protein (CRP) plays a vital role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release. It also regulates the production of interleukin-6 and tumor necrosis factor-α. Patients suffering from appendicitis, cholecystitis, pancreatitis, and meningitis have elevated levels of CRP. CRP facilitates the uptake of low-density lipoprotein in macrophages. It has a crucial role in the pathophysiology of cardiovascular disease, which makes it a useful marker for inflammation and cardiovascular events.

Quality

No precipitin bands when tested at 2 mg/mL against anti-whole human serum.

Physical form

Liquid in 100mM NaCl, 10mM Tris-HCl with 0.1% sodium azide, 2mM CaCl₂

Storage and Stability

Maintain under sterile conditions at 2-8°C for up to one year. Do not freeze. Full safety precautions should be taken as in the handling of any potentially infective body fluid.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

biological source: human. Quality Level: 100, 300. Assay: >. 98% (SDS-PAGE). form: liquid. manufacturer/tradename: Chemicon^®. . concentration: 3.5 . mg/mL. NCBI accession no.: NM_000567.2. UniProt accession no.: P02741. Storage Class Code: 12 - Non Combustible Liquids. WGK: nwg. Flash Point(F): Not applicable. Flash Point(C): Not applicable.