A single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, Factors XIa. XIIa, and plasmin. Present in plasma at 16-33 mg per 100 ml. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary, though it may also occur when the C1EI is non-functional.Product Citation:Salvesen, G.S et al. 1985. J. Biol. Chem. 260, 2432.Lee, Kyoung Geun, Haneulnari Lee, Jeong Mi Ha, Young Kyung Lee, Hee Jung Kang, Chung‐Gyu Park, and Sang Joon Kim. "Increased human tumor necrosis factor‐α levels induce procoagulant change in porcine endothelial cells in vitro."Xenotransplantation 19, no. 3 (2012): 186-195Kang, Hee Jung, Haneulnari Lee, Jeong-mi Ha, Jae-il Lee, Jun-Seop Shin, Ki-Yong Kim, Ji Yoon Park et al. "The Role of the Alternative Complement Pathway in Early Graft Loss After Intraportal Porcine Islet Xenotransplantation." Transplantation (2014)Kenninston JA, et al. Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody. J Biol Chem. 2014 Aug 22;289(34):23596-608. doi: 10.1074/jbc.M114.569061. Epub 2014 Jun 26.Zamolodchikov D, Renner T, Strickland S.The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.J Thromb Haemost. 2016 May;14(5):995-1007. doi: 10.1111/jth.13209. Epub 2016 Feb 29.
Specification: ≥95%(SDS-PAGE), Extinction Coefficient: 0.4
- UPC:
- 51111735
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- np001119-1mg
- Product Size:
- 1mg
