C5 LENALIDOMIDE-DIFLUOROPEG1-C4-PIPERAZINE HYDROCHLORIDE (C15-1313-312)

Application

Protein degrader building block C5 Lenalidomide-difluoroPEG₁-C₄-piperazine Hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a fluorinated linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.


Targeted Protein Degradation

Molecular Weight: 551.58 (free base basis). Empirical Formula: C₂₆H₃₅F₂N₅O₆ · xHCl. Quality Level: 100. Assay: ≥. 95%. form: powder. storage temp.: 2-8°C. SMILES string: O: C1N(C2CCC(NC2: O): O)CC3: CC(NC(COCC(F)(F)COCCCCN4CCNCC4): O): CC: C31.Cl. Pictograms: GHS08. Signal Word: Warning. Hazard Statements: H361d - H373. Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501. Hazard Classifications: Repr. 2 - STOT RE 2. Target Organs: Blood. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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