C57MG MOUSE MAMMARY EPITHELIAL CELLS (C005B-315613)

General description

Carcinomas arising from epithelial cells lining the mammary glands comprise the overwhelming majority of breast cancer cases (1). Transformation of mammary epithelial cells from their normal non-proliferative condition to an immortal state enabling hyperproliferation and malignancy occurs via bypass of senescence checkpoints. Cellular models that allow study of the mechanisms giving rise to malignancy are of paramount importance to the identification of therapeutic targets for breast cancer treatment.
The C57MG immortalized mammary epithelial cell line is an established model for mammary epithelial malignancy. C57MG cells are syngeneic with the C57BL/6 mouse model and have demonstrated potential of transformation with many proto-oncogenic factors. The C57MG cell line is widely used in studies of the role of Wnt signaling in malignant transformation (4). C57MG cells have been shown to upregulate expression of proto-oncogenic β-catenin in response to Wnt proteins (5). The features of the C57MG cell line make it a highly relevant model system for studies of breast cancer malignancy.

<bold>Source:</bold>
The C57MG cell line was established from mammary epithelial tissue of a C57BL/6 mouse (2).

Research Category:
Cancer

Cell Line Origin

Mouse, Epithelial Cells

Packaging

&ge;1X10⁶ cells/vial

Storage and Stability

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.