C75 trans

InformationC75 trans C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid syIn vitroC75 is toxic to prostate cancer cells. C75 reduces cell migration, while enhances radiation-induced clonogenic kill and enhances the spheroid growth delay induced by radiation exposure. Apoptosis induction by radiation exposure is enhanced by C75 treatment. C75 inhibits fatty acid synthesis and growth of established cancer cell lines from neu-N transgenic mice. C75 reduces the proliferation and expression of FAS, neu, and related genes in mammary epithelium.In vivoC75 inhibits fatty acid synthesis and in vivo mammary cancer development. C75 treatment prevents mammary cancer development and retards mammary development in neu-N transgenic mice.Cell Datacell lines：Glioma cell lines, BMDM, CRL-2467, HUVEC and HBMEC cell linesConcentrations：5 μM, 25 μM, 35 μM, 50 μMIncubation Time：3 h, 6 h, 24 hPowder Purity:≥98%. Specifications and Purity: 10mM in DMSO. Molecular Formula: C14H22O4. Molecular Weight: 254.32.