Caerulein Sulfated, 1mg

Caerulein is a gastroregulatory molecule with actions similar to cholecystokinin. Product supplied as a trifluoroacetate salt. Caerulein is used to study cell signaling mediated by NF-kappaB upregulation of proteins such as intercellular adhesion molecule-1(ICAM-1) and inflammation related molecules such as NADPH oxidase and Janus kinase signal transducer. It prevents gall bladder pain, renal colic, and the pain of intermittent claudication. The peptide is to be dissolved in distilled, oxygen free or preferable sterile oxygen free water first. The concentration should be high enough to allow addition of buffer after the products is dissolved completely. If necessary, diluted acetic acid or ammonium hydroxide, app. 1%, can be added to help solubilize the peptide. In those rare cases where solubilization is still not achieved, the solution may be sonicated briefly (up to 10 min, temperature shouldn't rise over 30-40 °C). In order to avoid serious solubility problems, buffer or saline should be added after the peptide is fully in solution. It is seen as an antagonist of endogenous opioids.