Calmodulin, Bovine Brain, High Purity (C15-1260-114)

General description

A ubiquitous Ca²⁺-binding protein distributed in eukaryotic cells that serves as a major physiological effector for a wide range of cellular responses. The Ca²⁺-calmodulin complex is involved in the maintenance of intracellular Ca²⁺ homeostasis, as well as in the regulation of the intracellular concentration of other second messengers, such as cyclic AMP and inositol trisphosphate. Calmodulin highly purified from bovine brain.



Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.

A ubiquitous Ca²⁺-binding protein that serves as a physiological effector of a wide range of biological processes. Calmodulin highly purified from bovine brain.

Note: this product cannot be used for animal treatment, in vivo research, or any contact procedure with livestock.

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Unit Definition

One unit is defined as the amount of calmodulin that gives rise to 50% of the maximal enzyme activation of a standard level of activator-deficient calcineurin.

Physical form

Lyophilized from 30 mM HEPES, 1 mM CaCl₂, 0.1 mM DTT, pH 7.4.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C or -70°C). Aqueous stock solutions are stable for up to 2 months at -20°C or for up to 4 months at -70°C.

Please refer to the vial label for lot-specific reconstitution volume.

Other Notes

Bagchi, I.C., et al. 1992. J. Biol. Chem.267, 3024.
O′Neil, K.T., and DeGrado, W.F. 1990. Trends Pharmacol. Sci. 15, 59.
Harrison, J.K., et al. 1988. J. Neurochem.51, 345.
Gopalakrishna, R., and Anderson, W.B. 1983. J. Biol. Chem.258, 2405.
Gopalakrishna, R., and Anderson, W.B. 1982. Biochem. Biophys. Res. Commun.104, 830.
Sharma, B.K., et al. 1979. Adv. Cyclic Nucleotide Res.10, 187.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany