General description
Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.
Application
Calyculin A from Discodermia calyx has been used:
- as an inhibitor of serine-threonine protein phosphatase 2A
- as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
- as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells
Biochem/physiol Actions
Calyculin A from Discodermia calyx binds to the okadaic acid receptors. In smooth muscles, it activates calcium channel. Calyculin A regulates protein phosphorylation thereby regulating capacitation in sperm. It enhances phosphorylation of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and apoptosis.
Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.
Features and Benefits
This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Shipping Information:
Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.
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- UPC:
- 12352200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- C5552-10UG
- CAS:
- 101932-71-2
