Cambinol (C09-0814-387)

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.application：Cambinol has been used:as an inhibitor of sirutins (SIRT1 and 2) in hepatocarcinoma cell lines to test its effect on cellular viability and colony formationas a SIRT1 and SIRT2 inhibitor to test its effect on frizzled 7 (FZD7) expression in the breast cancer cells MDA-MB-231 and T-47D cellsas a sirutin inhibitor in L929 cells to test its protective effect against tumor necrosis factor (TNF)-induced cell death.Biochemical mechanism:Cambinol is a Sirtuin (Human Silent Information Regulator) Type 1/2 Inhibitor. Sirtuins are structurally and mechanistically unrelated to HDACs Class 1 & 2 deacetylases but share many protein targets. HDAC is a large complex enzyme family involved in epigenetic-control of gene expression. Sirt2 has an IC50 equal to 59 μM.Cambinol, a β-naphthol compound, elicits antitumor activity and impairs the mitogen-activated protein kinase (MAPK) signaling. It has ability to inhibit the secretion of inflammatory cytokines including the tumor necrosis factor and interleukins. Cambinol can be a potential therapeutic agent for treating inflammatory diseases. It also aids protection in events of endotoxic and septic shock. Specification: ≥98% MDL Number: MFCD09057543 Molecular Formula: C21H16N2O2S Molecular Weight: 360.43 PubChem CID: 3246390 Isomeric SMILES: C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C274655-SCI_ae3c36b3cad1f2664e582f5a257ae82a.pdf