InformationAZD9833 is an orally available and selectiveestrogen receptor (ER)antagonist with antineoplastic activity.TargetsERIn vitroAZD9833 is demonstrated to be a highly potent selective estrogen receptor degraders (SERD) that shows a pharmacological profile comparable to fulvestrant in its ability to degrade ERα in both MCF-7 and CAMA-1 cell lines.In vivoA stringent control of lipophilicity ensures that AZD9833 has favorable physicochemical and preclinical pharmacokinetic properties for oral administration. AZD9833 is potent in vivo activity in mouse xenograft models.Cell Research(from reference)Cell lines：MCF-7 cells Concentrations：100 nM Incubation Time：24 h. Specifications and Purity: 99%. Molecular Formula: C24H28F4N6. Molecular Weight: 476.51. PubChem CID: 134453496. Isomeric SMILES: C[C@@H]1CC2=C(C=CC3=C2C=NN3)[C@H](N1CC(F)(F)F)C4=NC=C(C=C4)NC5CN(C5)CCCF.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A414295-5mg
- CAS:
- 2222844-89-3
- Product Size:
- 5mg
