General description
Carboplatin is used to treat testicular, ovarian and breast cancer.
Application
Carboplatin has been used:
- in chemotherapy-induced thrombocytopenia mouse model and treatment
- to induce cell death in a large subset of colorectal cancer cells
- in the evaluation of cell proliferation and chemosensitivity
- as a positive control for suppressed cell growth
Biochem/physiol Actions
Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
- UPC:
- 51112701
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- C2538-250MG
- CAS:
- 41575-94-4
