General description
Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Nitric oxide scavenging action
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
Other Notes
Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51283417
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 217386-10MG