Carcinoembryonic Antigen human

General description

Carcinoembryonic antigen(CEA) or CEA cell adhesion molecule 5 (CEACAM5), is encoded by the gene mapped to human chromosome 19q13.2. CEACAM5 is a member of the CEACAM family. This glycosylated protein contains a typical N-terminal variable immunoglobulin (Ig)-like domain, constant Ig-like domain, and a hydrophobic transmembrane domain with a glycosylphosphatidylinositol lipid moiety.

Application

Carcinoembryonic Antigen human has been used as a standard in electrochemical immunosensor and developed surface plasmon resonance imaging (SPRi) immunosensor. It has also been used as a tumor-associated antigen (TAA) in enzyme-linked immunosorbent assay

Biochem/physiol Actions

Carcinoembryonic antigen cell adhesion molecule 5 (CEACAM5) aids in cell adhesion and migration. In addition, this protein inhibits anoikis and thereby promoting tumorigenesis and metastasis. CEACAM5 is used as a biomarker to detect new cancer and cancer recurrence, particularly those with colorectal cancer. Upregulated expression of the gene enhances non-small-cell lung cancer (NSCLC) cell proliferation and invasion by regulating p38–Smad2/3 signaling. Therefore, CEACAM5 might be considered as an effective therapeutic target for treating NSCLC. Overexpression of the gene has also been observed in various types of cancer including gastrointestinal, pancreatic, and breast cancers.

Packaging

Package size based on protein content

Quality

Highly purified

Physical form

Solution in 0.15 M phosphate buffered saline, pH 7.4, containing 0.1% sodium azide.