General description
A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).
A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: no
Target Ki: 77 nM against Casein Kinase II
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Other Notes
Pagano, M.A., et al. 2006. Chembiochem8, 129
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 218710-5MG